Lung cancer overview
Lung cancer is the most frequently occuring cancer and the leading cause of cancer death. According to the WHO, there were over 2.2 million new cases of lung cancer globally in 2020, with over 1.75 million deaths. There are two main types of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer. About 80 to 85% of lung cancers are NSCLC, with three main subtypes, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
DKK1 is highly expressed in NSCLC and associated with shorter overall survival. DKN-01 has demonstrated activity as a monotherapy and in combination with chemotherapies and PD-1 antibody immune checkpoint inhibitors in preclinical models of NSCLC. In a clinical trial, DKN-01 demonstrated single agent activity in heavily-pretreated patients with NSCLC, including a patient with a partial response and nearly 50% of patients experiencing a best response of stable disease.