FL-501
Anti-GDF15 antibody
FL-501 antibody mechanism
FL-501 is a potential best in class antibody designed to neutralize GDF-15 and prevent the binding to its receptor. FL-501 was engineered for higher target affinity and a longer plasma half-life compared to competing therapies. In preclinical cachexia models, FL-501 increased body weight and restored muscle mass.
FL-501 may be expected to reverse immunosuppression in cancers where elevated GDF-15 is correlated with poor survival. FL-501 may also play a role in treating other GDF-15-related diseases.
Immunostimulation in tumor microenvironment
Weight gain, normal appetite, improved muscle mass
Improved maternal health
Renoprotective effects
Pulmonary improvement
Cardioprotective effects