FL-501
(NBL-016)

Anti-GDF15 antibody image description

 

FL-501 is a potential best in class antibody designed to neutralize GDF15 and prevent the binding to its receptor. FL-501 was engineered to have high affinity with improved half-life compared to other molecules of its class, which may result in significantly less frequent dosing. In pre-clinical models of cachexia increases in body weight have been observed following administration of the antibody.

In addition, FL-501 is expected to inhibit the activity of GDF15 in promoting an immunosuppressive tumor micro-environment in a broad range of cancers, including gastric, colorectal, pancreatic and prostate, where elevated GDF15 also correlates with poor prognosis.

 

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GDF15 is secreted to blood stream at elevated levels

GDF15 overexpression leads to Cachexia

  • Nausea
  • Loss of
    appetite
  • Decreased
    weight
  • Lower muscle
    mass

FL-501 prevents GDF15 from binding to GFRAL

  • Normal
    appetite
  • Normal
    weight
  • Normal
    muscle mass