Leap Therapeutics is a patient focused company.
We've all known someone important to us, a family member, friend, or co-worker, who has fought cancer. We admire the commitment of all of the patients who choose to enroll in clinical trials. We appreciate the dedication of the doctors, nurses, staff, and patient advocacy groups that support cancer patients and their loved ones. We work every day to develop new targeted therapies for cancer patients.
Click below to learn more about our clinical trials and for links to resources for patients.
|Trial number||Indication||Therapy||Trial name|
DKN-01 + tislelizumab + CAPOX
DKN-01 + tislelizumab
|NCT04166721||Gastroesophageal cancer||DKN-01 + Tecentriq®||WaKING|
|NCT05480306||Colorectal cancer||DKN-01 + bevacizumab||DeFianCe|
|NCT05761951||Endometrial сancer||DKN-01 + Keytruda®|
|NCT05153096||Claudin18.2 expressing solid tumors||NBL-015 (FL-301)|
Lung cancer is the most frequently occurring cancer and the leading cause of cancer death. According to the WHO, there were over 2.2 million new cases of lung cancer globally in 2020, with over 1.75 million deaths. There are two main types of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer. About 80 to 85% of lung cancers are NSCLC, with three main subtypes, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.
Colorectal cancer (CRC) is the third most frequent cancer globally and the second leading cause of death. According to the WHO, there were nearly 2 million new cases of colorectal cancer in 2020, with nearly 1 million deaths. Colorectal cancer includes colon cancer (57.5%), rectal cancer (35%), and anal cancer (2.5%). When the symptoms of CRC appear, such as rectal bleeding, anemia, or abdominal pain, most patients are already in the advanced stage where cancers are aggressive, malignant, and metastatic.
Endometrial cancer is the most common gynecologic cancer. The American Cancer Society estimates that about 66,200 new cases of endometrial cancer will be diagnosed in 2023 and that over 13,000 women will die of endometrial cancer.
Sourse: www.cancer.org, "Key Statistics for Endometrial Cancer"
Gastric cancer is the fourth leading cause of cancer death and a major global unmet medical need. According to the WHO, there were over 1 million new cases of gastric cancer globally in 2020, with over 750,000 deaths. Many people with gastric cancer have late-stage disease, because people usually do not have significant symptoms until the tumor is fairly large. In advanced stages, the cancer frequently spreads into the liver or lungs.
Prostate cancer is one of the most common types of cancer in men. According to the American Cancer Society, about 175,000 cases are diagnosed each year in the United States. Treatment options include the surgical removal of the prostate, radiation, as well as hormonal agents, many of which can result in poor side effects, such as urinary incontinence and erectile dysfunction. Most prostate cancer tumors become resistant to hormonal therapies, which is referred to as castration-resistance prostate cancer.