Leap Therapeutics History
Our History
First patient dosed with TRX518 001
Collaboration with Merck KGaA, Darmstadt, Germany and Pfizer for TRX518
Collaboration with Merck KGaA, Darmstadt, Germany and Pfizer for TRX518
First patient dosed with TRX518 001


Collaboration with Merck KGaA, Darmstadt, Germany and Pfizer for TRX518
Collaboration with Merck KGaA, Darmstadt, Germany and Pfizer for TRX518
Collaboration with Merck KGaA, Darmstadt, Germany and Pfizer for TRX518
Team

Luke Andersen
Finance
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Jay Baum, Ph.D.
Translational Medicine

Amy Belliveau
Manufacturing

Greg Bremer
Manufacturing

Adam Connelly
Manufacturing

Alex V. De Windt, MD
Pharmacovigilance

Christine Granfield
Regulatory

Michael Haas, Ph.D.
Research

Peter Hocknell, Ph.D.
Manufacturing

Michael Kagey, Ph.D.
Research

Cliff Kwityn
Manufacturing
Gus Lawlor
Chief Operating Officer

Matthew Lederhos
Finance

Kevin Lloyd
Program & Alliance Management

Jonathan Miller
Business Development
Chris Mirabelli, Ph.D.
Chairman of the Board
Walter Newman, Ph.D.
Senior Research Fellow
Mark O'Mahony
Chief Manufacturing Officer
Douglas Onsi
President & CEO

Diane Piper
Clinical

Lianna Sifferlen
Clinical
Cyndi Sirard, M.D.
Chief Medical Officer

Robert Steinberg
Operations

Steve Tokatlyan
Operations
2006
First US patent filed for TRX518
2009
First patient dosed with DKN-01 by Eli Lilly
2010
First patient dosed with TRX518 at Memorial Sloan Kettering Cancer Center
2010
First US patent granted covering sequence of DKN-01
2016
Leap Therapeutics launched
2017
Leap Therapeutics becomes publicly listed on NASDAQ: LPTX
2017
Initiated collaboration with Merck to evaluate DKN-01 in combination with Keytruda
2018
Initiated collaboration with Pfizer/Merck KGaA to evaluate TRX518 in combination with Bavencio
2020
Leap Therapeutics and BeiGene Announce Exclusive Option and License Agreement for DKN-01
2020
Leap Therapeutics Announces Orphan Drug Designation of DKN-01 for the Treatment of Gastric/Gastroesophageal Junction Cancer and Closes $45 million Public Offering of Common Stock
Board of Directors
Chris Mirabelli, Ph.D.
Chairman of the Board, Leap Therapeutics
Chairman and CEO of Waypoint Holdings
Doug Onsi, J.D.
President & CEO, Leap Therapeutics
Co-Founder of NuBiyota
James Cavanaugh, Ph.D.
Managing Director at HealthCare Ventures
CEO and President of Angiogenesis Foundation
Joseph Loscalzo, M.D., Ph.D, M.A.
Chairman, Department of Medicine, Physician-in-Chief, Brigham and Women’s Hospital
Monica M. Bertagnolli, MD, FASCO
Chief, Division of Surgical Oncology, Dana-Farber/Brigham and Women's Cancer Center; Professor of Surgery, Harvard Medical School, Boston
Scientific Advisory Board
David Tuveson, M.D., Ph.D.
Chair of Leap SAB, Director of Research, the Lustgarten Foundation, Roy J. Zuckerberg Professor of Cancer Research at Cold Spring Harbor Laboratory
Endowed Research Chair, Professor of Neurology, American Cancer Society Research Professor, Boston Children’s Hospital and Harvard Medical School
Senior Vice President and Chief Clinical Strategy Officer; Chief, Division of Women's Cancers, Dana Farber Cancer Institute; Director, Breast Oncology Program, Susan F. Smith Center for Women's Cancers; Thompson Chair in Breast Cancer Research Institute Physician; Professor of Medicine, Harvard Medical School
Professor of Immunology and Infectious Disease at the Harvard T.H. Chan School of Public Health and Associate Professor of Medicine at Harvard Medical School. Physician at Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, MA
Professor and Chairman of Department of Microbiology and Immunology at Weill Cornell Medical College
Professor of Medicine at Duke University Medical Center, Director of the Phase I Biomarker Laboratory and Associate Director of the Duke Center for Cancer Immunotherapy